ESSAYS ON APS CLASSIC PAPERS Synaptic chemistry in single neurons: GABA is identified as an inhibitory neurotransmitter
نویسنده
چکیده
This essay looks at the historical significance of two APS classic papers that are freely available online: Kravitz EA, Kuffler SW, and Potter DD. Gamma-aminobutyric acid and other blocking compounds in Crustacea. III. Their relative concentrations in separated motor and inhibitory axons. J Neurophysiol 26: 739–751, 1963 (http:// jn.physiology.org/cgi/reprint/26/5/739). Otsuka M, Kravitz EA, and Potter DD. Physiological and chemical architecture of a lobster ganglion with particular reference to gamma-aminobutyrate and glutamate. J Neurophysiol 30: 725–752, 1967 (http://jn.physiology.org/cgi/reprint/ 30/4/725).
منابع مشابه
Synaptic chemistry in single neurons: GABA is identified as an inhibitory neurotransmitter.
This essay looks at the historical significance of two APS classic papers that are freely available online: Kravitz EA, Kuffler SW, and Potter DD. Gamma-aminobutyric acid and other blocking compounds in Crustacea. III. Their relative concentrations in separated motor and inhibitory axons. J Neurophysiol 26: 739–751, 1963 (http:// jn.physiology.org/cgi/reprint/26/5/739). Otsuka M, Kravitz EA, an...
متن کاملOptogenetics: Control of Brain Using Light
Neuronal cells communicate with each other by producing electrical signals or action potentials (APs). Different ion channels, including Na+, K+ and Ca2+ channels, are involved in generation of AP. Once an AP is generated in the soma, it travels down entire the axon length toward its terminal in a self-generating fashion that ultimately conveys information between neurons in the neural circuit....
متن کاملESSAYS ON APS CLASSIC PAPERS What do dendrites and their synapses tell the neuron?
This essay looks at the historical significance of four APS classic papers that are freely available online: Rall W. Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. J Neurophysiol 30: 1138–1168, 1967 (http://jn.physiology.org/cgi/reprint/30/5/1138). Rall W, Burke RE, Smith TG, Nelson PG, and Frank K. Dendritic location of syn...
متن کاملProtracted postnatal development of inhibitory synaptic transmission in rat hippocampal area CA1 neurons.
In the CNS, inhibitory synaptic function undergoes profound transformation during early postnatal development. This is due to variations in the subunit composition of subsynaptic GABA(A) receptors (GABA(A)Rs) at differing developmental stages as well as other factors. These include changes in the driving force for chloride-mediated conductances as well as the quantity and/or cleft lifetime of r...
متن کاملActivity-Dependent Tuning of Inhibitory Neurotransmission Based on GABAAR Diffusion Dynamics
An activity-dependent change in synaptic efficacy is a central tenet in learning, memory, and pathological states of neuronal excitability. The lateral diffusion dynamics of neurotransmitter receptors are one of the important parameters regulating synaptic efficacy. We report here that neuronal activity modifies diffusion properties of type-A GABA receptors (GABA(A)R) in cultured hippocampal ne...
متن کامل